Advanced glycation end-product (AGE) pathway (AGE pathway; AGEs (for the compounds); RAGE (for the receptor))

Advanced glycation end-product pathway refers to the non-enzymatic chemical modification of proteins, lipids, and nucleic acids by reducing sugars, leading to the formation of advanced glycation end-products (AGEs). The process involves several steps, including the Maillard reaction, and accelerates under hyperglycemic and oxidative conditions. AGEs accumulate with age and in various diseases, especially diabetes, and promote structural and functional damage to tissues by forming protein cross-links and by binding to cellular receptors like RAGE, which triggers inflammation, oxidative stress, and fibrosis. This pathway is implicated in numerous chronic conditions, making both AGEs and their primary receptor (RAGE) the focus of diagnostic and therapeutic strategies[1][5][7][9].

Other names

Advanced glycation end-products pathwayMaillard reaction pathwayAGE–RAGE axis

AGE cross-link breaking; Inhibition of AGE formation (by scavenging intermediates); RAGE antagonism or blockade; Enhancement of AGE clearance (e.g., glyoxalase induction)