Advanced Glycation End Product Formation Pathway (AGE Pathway)

The advanced glycation end product (AGE) formation pathway is a series of non-enzymatic chemical reactions in which reducing sugars react with proteins, lipids, or nucleic acids, leading to the formation of AGEs. This process involves the Maillard reaction, polyol pathway, lipid peroxidation, Wolff pathway, and Namiki pathway, and is implicated in the pathogenesis of various chronic diseases and aging-related tissue damage. Key intermediates include Schiff bases, Amadori products, methylglyoxal, and glyoxal. AGEs accumulate and lead to protein cross-linking, loss of protein function, increased tissue stiffness, and activation of inflammatory signaling via specific receptors such as RAGE, AGE-R1, AGE-R2 and AGE-R3.

Other names

Maillard Reaction PathwayGlycation PathwayAGEs Formation

Inhibition of AGE formation, scavenging of AGEs or AGE precursors, blocking AGE receptor interaction