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Advanced Glycation End-Product Receptor Signaling Pathway
- Molecular classification
- Signaling Pathway
01
Overview
The AGE-RAGE signaling pathway centers on the interaction between advanced glycation end-products (AGEs) and their primary cell surface receptor, RAGE (Receptor for Advanced Glycation End Products). AGEs are heterogeneous compounds formed through non-enzymatic reactions between reducing sugars and proteins, lipids, or nucleic acids—a process accelerated in hyperglycemia and aging. The binding of AGEs to RAGE initiates a cascade of intracellular signaling events that drive inflammation, oxidative stress, cellular dysfunction, and tissue damage.
02
Biological functions
Signal transductionInflammationOxidative stressCellular dysfunction
03
Disease associations
DiabetesAtherosclerosisAlzheimer's diseaseInflammationAgingRenal failureAmyloidosesCardiovascular Disease
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