Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Advanced Glycation End-Products (AGEs)
- Target
- AGEs
- Molecular classification
- Modified proteins, Modified lipids, Modified nucleic acids
01
Overview
Advanced glycation end-products (AGEs) are a heterogeneous group of compounds formed through non-enzymatic reactions between reducing sugars and proteins, lipids, or nucleic acids. They accumulate in tissues over time and are implicated in the development or progression of several degenerative diseases, primarily through promoting oxidative stress and inflammation.
- Other names
- Glycation end productsAdvanced glycosylation end products
02
Mechanism of action
N/A
03
Biological functions
InflammationOxidative stressTissue damageProtein crosslinking
04
Disease associations
Diabetic complicationsCardiovascular diseasesChronic kidney diseaseAlzheimer’s diseaseAging
05
Safety considerations
Accumulation in tissuesPromotion of inflammationPromotion of oxidative stress
06
Biomarkers
Nε-carboxymethyl-lysine (CML)Nε-carboxyethyl-lysine (CEL)PyrralinePentosidine
Beyond the preview
Go deeper on Advanced Glycation End-Products (AGEs).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Advanced Glycation End-Products (AGEs).