AE binding protein 2 (AEBP2)

AE binding protein 2 (AEBP2) is a zinc finger DNA-binding transcriptional repressor and accessory subunit of the Polycomb Repressive Complex 2 (PRC2)[1][2][3][4][5][6]. It is evolutionarily conserved, binds DNA at specific sequence motifs, and serves both as a structural stabilizer and recruitment scaffold within PRC2, facilitating PRC2's ability to methylate histone H3 at lysine 27 (H3K27), leading to gene silencing[1][2][3][4][5][6]. AEBP2 is expressed in multiple developmental stages (via alternative promoters), regulates neural crest cell migration and development through PRC2-mediated mechanisms, and participates in targeting PRC2 to chromatin sites[3][4][5]. AEBP2 has been linked to several human diseases, including Weaver syndrome, Waardenburg's syndrome, Hirschsprung's disease, and certain cancers, primarily via its modulatory effects on PRC2-dependent gene regulation[3][5]. There is no evidence that AEBP2 itself is currently a direct therapeutic target or biomarker, nor are there any specific drugs known to interact directly with it; its clinical significance arises from its essential role in regulating PRC2 activity and chromatin state[1][3][5][6].

Other names

AE-binding protein 2Adipocyte enhancer-binding protein 2Zinc finger protein AEBP2MGC17922AE (adipocyte enhancer)-binding protein 2