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Target intelligence / Profile preview
AFe(II)-protoporphyrin IX (Heme)
- Target
- Heme
- Molecular classification
- Prosthetic group, Porphyrin, Cofactor
01
Overview
AFe(II)-protoporphyrin IX, also known as heme, is the iron(II) complex of protoporphyrin IX. It is a crucial prosthetic group found in hemoproteins such as hemoglobin, myoglobin, cytochromes, peroxidases, and catalases. Heme is responsible for oxygen binding, electron transfer, and enzymatic catalysis. It plays a vital role in cellular respiration and other essential biological processes.
- Other names
- HemeProtohemeProtoheme IXHaemHeme b
02
Mechanism of action
Binding to heme iron, altering oxygen binding affinity or inhibiting heme-containing enzymes.
03
Biological functions
Oxygen transportOxygen storageElectron transferEnzymatic catalysis
04
Disease associations
PorphyriaAnemiaIron deficiencyHemoglobinopathies
05
Safety considerations
Heme toxicity at high concentrationsPotential for iron overloadInterference with heme-dependent enzyme function
06
Interacting drugs
Carbon monoxide
2 more in the full profile.
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