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Target intelligence / Profile preview
African Swine Fever Virus p54 Protein (p54)
- Target
- p54
- Molecular classification
- Viral protein, Type I transmembrane protein
01
Overview
The African swine fever virus (ASFV) p54 protein is a critical structural and functional component of the ASFV virion. It is encoded by the E183L gene and has a molecular weight of approximately 25 kDa. The protein is classified as a type I transmembrane protein, localizing predominantly to the external envelope of the virus and associating with endoplasmic reticulum (ER)-derived membranes during viral assembly. It is essential for recruitment and transformation of ER membranes into viral envelope precursors, facilitating intracellular transport of viral capsids. It also plays a role in virus attachment to target cells. p54 is highly immunogenic, inducing neutralizing antibodies upon infection or immunization and is considered a potential vaccine candidate.
- Other names
- E183L protein
02
Mechanism of action
Antibody neutralization of viral entry/assembly
03
Biological functions
Virion assemblyViral envelope formationIntracellular transportHost cell interactionImmune response induction
04
Disease associations
African Swine FeverInfection
05
Safety considerations
Potential for off-target effects with antiviral therapies targeting p54Development of resistant viral strains
06
Biomarkers
p54 expression levels for viral detectionAnti-p54 antibody titers for immune response monitoring
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