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Target intelligence / Profile preview
Ag85B protein
- Molecular classification
- Enzyme, Mycolyltransferase
01
Overview
Ag85B is a major secreted protein of Mycobacterium tuberculosis and part of the antigen 85 (Ag85) complex. It functions as a mycolyl transferase, catalyzing transesterification reactions essential for the biosynthesis of key cell wall components like TMM and TDM. It is crucial for bacterial survival and considered a leading drug target for new antituberculous therapies. Ag85B is also highly immunogenic and a component in several candidate TB vaccines.
- Other names
- Antigen 85 complex BMycolyl transferase 85BfbpBDiacylglycerol acyltransferase/mycolyltransferase Ag85B
02
Mechanism of action
Inhibition of mycolyl transferase activity
03
Biological functions
Cell wall biosynthesisMycolyl transferase activityAdhesionImmune response
04
Disease associations
InfectionTuberculosis
05
Safety considerations
Potential for off-target effects if inhibitors are not specific to mycobacterial Ag85BDevelopment of resistance to inhibitors
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