Target intelligence / Profile preview

Agglutinin-like sequence 3 protein (Als3)

Target: Als3
Molecular classification: Adhesin, Glycoprotein

Overview

Agglutinin-like sequence protein 3 (Als3) is a cell surface glycoprotein found in the pathogenic yeast Candida albicans. It is a member of the ALS (agglutinin-like sequence) gene family, which encodes large cell-surface adhesins critical for fungal adherence, biofilm formation, and virulence. Als3 mediates attachment of C. albicans to host tissues and medical devices. It plays an essential role in biofilm development and facilitates invasion by inducing endocytosis.

Mechanism of action

Inhibition of Als3 function to disrupt adhesion and biofilm formation.

Biological functions

AdhesionBiofilm formationVirulenceIron acquisition

Disease associations

InfectionInvasive candidiasisDevice-associated infections

Safety considerations

Potential for off-target effects due to sequence similarity with other ALS proteins.Development of resistance to anti-Als3 therapies.

Interacting drugs

Fluconazole

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