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Agouti-Related Protein (AgRP)
- Target
- AgRP
- Molecular classification
- Neuropeptide, Signaling molecule
01
Overview
Agouti-related protein (AgRP) is a neuropeptide primarily produced in the arcuate nucleus of the hypothalamus. It acts as an endogenous antagonist of melanocortin receptors MC3R and MC4R, stimulating appetite and reducing energy expenditure. It plays a central role in regulating energy balance, food intake, and body weight. Dysregulation of AgRP is linked to obesity and metabolic disorders.
- Other names
- Agouti-related peptide
02
Mechanism of action
Antagonism of MC3R and MC4R melanocortin receptors
03
Biological functions
Appetite regulationEnergy homeostasisGlucose homeostasisNeuroendocrine modulationMelanocortin receptor antagonism
04
Disease associations
ObesityType II DiabetesMetabolic disorders
05
Safety considerations
Potential for weight gain if over-inhibitedDisruption of metabolic homeostasis
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