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Aiolos (IKZF3)
- Target
- IKZF3
- Molecular classification
- Transcription factor, Ikaros family zinc-finger proteins
01
Overview
Aiolos, encoded by the IKZF3 gene, is a hematopoietic-specific transcription factor belonging to the Ikaros family of C2H2-type zinc-finger proteins. It plays a crucial role in regulating B-cell differentiation, proliferation, and maturation, as well as T cell development and chromatin remodeling. Aiolos functions through homo- and heterodimerization with other Ikaros family members. Aberrant Aiolos function is implicated in primary immunodeficiencies, autoimmune diseases, and hematologic malignancies.
- Other names
- Zinc finger protein AiolosIkaros family zinc finger protein 3ZNFN1A3
02
Mechanism of action
N/A
03
Biological functions
B-cell differentiationB-cell proliferationB-cell maturationRegulation of apoptosisChromatin remodelingT cell developmentImmune homeostasis
04
Disease associations
Primary immunodeficienciesImmune thrombocytopeniaSystemic lupus erythematosusRheumatoid arthritisChronic lymphocytic leukemia (CLL)Acute lymphoblastic leukemia (ALL)
05
Safety considerations
Potential for autoimmunity or malignancy upon disruption of normal function.
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