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Aiolos transcription factor (IKZF3)

Target: IKZF3
Molecular classification: Transcription factor, Ikaros zinc-finger transcription factors

Overview

Aiolos, encoded by the *IKZF3* gene, is a member of the Ikaros family of zinc-finger transcription factors primarily expressed in lymphoid tissues. It regulates proliferation and differentiation of lymphocytes and participates in chromatin remodeling. Aiolos is involved in key functions such as apoptosis regulation via direct control of Bcl-2 expression and is implicated in hematological malignancies. It is a target for PROTAC-based therapeutic strategies.

Other names: Ikaros family zinc finger protein 3Zinc finger protein Aiolos

Mechanism of action

Targeted protein degradation via E3 ubiquitin ligases (e.g., cereblon (CRBN)) and the proteasome pathway.

Biological functions

Lymphocyte developmentLymphocyte differentiationChromatin remodelingApoptosis regulationRegulation of BCL2 expressionRegulation of BCL6 expressionRegulation of CXCR3 expressionModulates IFN-γ/STAT signaling

Disease associations

LeukemiaHematologic malignanciesChronic lymphocytic leukemia (CLL)

Safety considerations

Potential for off-target effects with PROTACs targeting IKZF family membersDysregulation of immune cell development and function

Interacting drugs

Thalidomide analogs (PROTACs)

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