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Target intelligence / Profile preview
Airway Basal Progenitor Cells (ABPCs)
- Target
- ABPCs
- Molecular classification
- Stem cell, Progenitor cell
01
Overview
Airway basal progenitor cells are specialized epithelial stem/progenitor cells located along the basement membrane of the airway epithelium. They play a central role in maintaining airway homeostasis and mediating regeneration after injury by differentiating into various cell types that constitute the airway lining, including ciliated and secretory (goblet) cells. This regenerative process is essential for repairing damage to the protective epithelial barrier following insults such as infection, inflammation, or exposure to toxins. Their dysfunction or exhaustion is linked to impaired repair mechanisms as seen in COPD.
- Other names
- Basal cells of the airway epitheliumAirway stem cellsKRT5+ cellsTP63+ cells
02
Mechanism of action
N/A
03
Biological functions
Tissue regenerationAirway homeostasisEpithelial differentiationWound healingCell proliferationCell migrationECM remodeling
04
Disease associations
COPDLung injuryAirway remodelingHyperplasiaPotential role in tumorigenesis/cancer
05
Safety considerations
HyperplasiaPotential for tumorigenesis with dysregulated regeneration
06
Biomarkers
TP63KRT5KRT14YAP1
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