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Target intelligence / Profile preview
Airway Epithelial Cilia (Cilia (Airway Epithelial))
- Target
- Cilia (Airway Epithelial)
- Molecular classification
- Microtubule-based structures, Cellular appendages
01
Overview
Airway epithelial cilia are motile, hair-like projections on the surface of airway epithelial cells. Their coordinated beating facilitates mucociliary clearance, removing inhaled particles and pathogens from the respiratory tract. Each cilium contains an axoneme with a "9+2" microtubule arrangement, and its movement is powered by dynein arms. Dysfunction of cilia leads to impaired clearance and contributes to obstructive lung diseases.
- Other names
- Airway ciliaRespiratory ciliaTracheal ciliaBronchial cilia
02
Biological functions
Mucociliary clearanceAirway defenseParticle removalPathogen clearance
03
Disease associations
COPDAsthmaPrimary Ciliary Dyskinesia (PCD)Cystic FibrosisBronchiectasisRespiratory infections
04
Safety considerations
Ciliary dysfunction can lead to increased susceptibility to respiratory infectionsImpaired mucociliary clearance can exacerbate underlying lung diseases
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