Airway inflammation mediators

Airway inflammation mediators are a diverse group of molecules—including cytokines (such as IL-6, IL-8, and IL-33), chemokines, lipid-derived mediators (prostaglandins, leukotrienes, lipoxins), biogenic amines (histamine, serotonin), peptides (bradykinin), and growth factors—released by airway and immune cells in response to injury, infection, or allergen challenge. These mediators coordinate the recruitment and activation of inflammatory cells, promote bronchoconstriction, mucus secretion, vascular permeability, and contribute to the pathology of diseases such as asthma, COPD, and viral-induced airway disorders. Due to their heterogeneous nature, "airway inflammation mediators" does not represent a single molecular target, but rather an overlapping set of potential therapeutic targets within the complex inflammatory network of the airways[4][1][5][6][7].

Other names

Airway inflammatory mediatorspro-inflammatory mediators in the airwaychemical mediators of airway inflammation

Receptor antagonism (e.g., histamine receptor blockers, leukotriene receptor blockers) Anti-inflammatory effects (corticosteroids decrease mediator release) Enzyme inhibition (e.g., COX inhibitors reduce prostaglandin synthesis) Inhibition of cell degranulation (mast cell stabilizers)