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Target intelligence / Profile preview
Airway mucus glycosaminoglycans (GAGs)
- Target
- GAGs
- Molecular classification
- Glycosaminoglycan, Polysaccharide, Other
01
Overview
Airway mucus mucopolysaccharides, now scientifically recognized as airway glycosaminoglycans (GAGs), are complex, long-chain polysaccharides that are integral components of the respiratory tract's protective mucus layer (PubMed, PMID: 15104163). These molecules, which include}
- Other names
- Airway mucus mucopolysaccharidesAcid mucopolysaccharidesRespiratory glycosaminoglycansMucus polysaccharidesAirway GAGs
02
Mechanism of action
Reduction of mucus viscosity and enhancement of mucociliary clearance through the disruption of disulfide bonds in mucins, enzymatic degradation of DNA and polysaccharides, or osmotic hydration of the glycosaminoglycan-rich mucus matrix.
03
Biological functions
Immune responseHydrationLubricationPathogen trappingViscoelasticity regulationOther
04
Disease associations
InfectionInflammationCystic fibrosisChronic obstructive pulmonary diseaseAsthmaBronchiectasisOther
05
Safety considerations
BronchospasmAirway hyperresponsivenessMucosal irritationCoughDisruption of the protective epithelial barrier
06
Interacting drugs
Acetylcysteine
7 more in the full profile.
07
Biomarkers
Sputum viscosityMucociliary clearance rateSputum glycosaminoglycan concentrationForced expiratory volume in 1 second (FEV1)
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