Target intelligence / Profile preview

Airway obstruction

01

Overview

Airway obstruction refers to any blockage that hinders the free flow of air through the respiratory tract. It can occur in either the upper or lower parts of the airway. Causes include swelling and mucus production from conditions like asthma or COPD, foreign bodies (such as food or toys), trauma, allergic reactions, burns, chemicals, and congenital abnormalities. Symptoms may include coughing, wheezing (especially with lower airway involvement), stridor (with upper airway involvement), shortness of breath, rapid breathing and heartbeat. Severe cases can lead to agitation, loss of consciousness or death if untreated. Diagnosis often involves clinical assessment and tests such as spirometry for chronic cases. Treatment depends on cause but may involve removing blockages physically or medically using bronchodilators or anti-inflammatory drugs; severe cases require urgent intervention including oxygen therapy and sometimes mechanical ventilation.

Other names
Upper airway obstructionLower airway obstructionPartial airway obstructionComplete airway obstructionBlockage of the airway
02

Mechanism of action

Bronchodilators relax and widen airways to improve airflow. Inhaled corticosteroids decrease inflammation in the airways.

03

Disease associations

Other (Airway obstruction is a clinical condition or symptom rather than a molecular target; it is associated with diseases such as asthma, chronic obstructive pulmonary disease (COPD), bronchitis, and trauma)
04

Safety considerations

Airway obstructions can be life-threatening if not treated promptly.Chronic hypoxiaCor pulmonale (right-sided heart failure)Increased risk of infections like pneumonia
05

Interacting drugs

Bronchodilators

2 more in the full profile.

06

Biomarkers

Decreased FEV1/FVC ratio on spirometry for lower airway obstructions

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