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Airway Sensory Nerve C-Fiber (None)
- Target
- None
- Molecular classification
- Sensory Neuron, Nociceptor, Primary Afferent Neuron
01
Overview
Airway sensory nerve C-fibers are unmyelinated primary afferent neurons that innervate the respiratory tract and play a critical role in detecting noxious and inflammatory stimuli. They mediate defensive reflexes like cough and bronchoconstriction, and contribute to neurogenic inflammation via neuropeptide release. They are activated by chemical irritants, inflammatory mediators, and specific agonists like capsaicin, primarily through TRPV1 and TRPA1 channels. Overactivation or sensitization of these fibers is implicated in chronic respiratory diseases.
- Other names
- Airway C-fiberBronchial C-fiberPulmonary C-fiberJuxtacapillary receptorsJ-receptors
02
Mechanism of action
Modulation of ion channel activity (e.g., TRPV1, TRPA1), neuropeptide release inhibition, anti-inflammatory effects
03
Biological functions
NociceptionSensory transductionDefense reflexes (cough, bronchoconstriction, mucus secretion)Neurogenic inflammationAxon reflex
04
Disease associations
Chronic coughAsthmaCOPDAirway inflammationRespiratory infections
05
Safety considerations
Non-selective modulation may affect other sensory pathwaysPotential for paradoxical effects (e.g., cough induction)Desensitization or tachyphylaxis with prolonged exposure to agonists
06
Interacting drugs
Capsaicin
4 more in the full profile.
07
Biomarkers
Substance PCGRPTRPV1 expression levelsTRPA1 expression levels
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