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Target intelligence / Profile preview
Airway Smooth Muscle Cell Membrane (ASM Cell Membrane)
- Target
- ASM Cell Membrane
- Molecular classification
- Cell Membrane, Lipid Bilayer, Receptor Complex, Ion Channel Complex, Adhesion Molecule Complex
01
Overview
The airway smooth muscle (ASM) cell membrane is the specialized plasma membrane that surrounds airway smooth muscle cells, which are found throughout the respiratory tract. This membrane plays a central role in regulating airway tone, structure, and function by mediating contraction, relaxation, cell signaling, and interactions with other cells and extracellular matrix components. It contains receptors, ion channels, and adhesion molecules, which are important drug targets for respiratory diseases.
- Other names
- ASM MembraneAirway Smooth Muscle Plasma Membrane
02
Mechanism of action
Modulation of contractility or immune responses mediated at the level of the ASM cell membrane
03
Biological functions
Signal TransductionCell AdhesionContraction and Relaxation of Smooth MuscleIon TransportImmunomodulationSecretion
04
Disease associations
AsthmaChronic Obstructive Pulmonary Disease (COPD)Airway HyperresponsivenessAirway RemodelingBronchoconstriction
05
Safety considerations
Over-stimulation of β2-adrenergic receptors can lead to tachycardia and tremors.Muscarinic antagonists can cause dry mouth and blurred vision.
06
Interacting drugs
β2-Adrenergic agonists
2 more in the full profile.
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