Akirin-1 (AKIRIN1)

Akirin-1 is a small (~22 kDa), highly conserved nuclear protein that acts as a transcriptional cofactor or molecular adapter, primarily facilitating communication between signaling pathways, chromatin remodelers, and transcription factors involved in gene regulation[1][2][3]. It is particularly important in skeletal muscle development and regeneration, where it mediates pathways controlling myoblast differentiation and migration, responding to signals such as myostatin (MSTN). Although Akirin-1 does not contain recognizable DNA-binding or catalytic domains, it orchestrates protein-protein interactions central to gene expression regulation. Unlike its paralog Akirin-2, Akirin-1 is non-essential for embryonic survival in mice, but its deficiency influences muscle fiber phenotype and regeneration efficiency. Disease associations include rare congenital myopathies. There is no evidence that Akirin-1 is currently targeted directly by any drugs or used as a clinical biomarker[1][2][3].

Other names

C1orf108FLJ12666STRF2Mighty (in earlier literature)Akirin-1AKIRIN1

Not applicable: No drugs target Akirin-1