Target intelligence / Profile preview

AKT Kinase (PKB)

Target: PKB
Molecular classification: Enzyme, Kinase, Serine/threonine kinase, AGC kinase

Overview

AKT kinase, also known as protein kinase B (PKB), is a serine/threonine-specific protein kinase that plays a central role in regulating metabolism, cell growth, survival, and cellular transformation. It is a key player in the PI3K–AKT–mTOR signaling pathway.

Other names: Protein Kinase B

Mechanism of action

AKT inhibitors block the kinase activity of AKT, inhibiting downstream signaling.

Biological functions

Cell survivalApoptosis inhibitionMetabolic regulationCell proliferationLysosomal biogenesisAutophagyAngiogenesisSignal transduction

Disease associations

CancerDiabetesCardiovascular diseaseNeurological diseasesAutoimmunity

Safety considerations

Potential for off-target effects due to kinase family similarity.Development of resistance mechanisms.

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