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Target intelligence / Profile preview
AKT Kinase Pathway (PI3K-AKT)
- Target
- PI3K-AKT
- Molecular classification
- Signal Transduction Pathway
01
Overview
The AKT kinase pathway, also known as the PI3K-AKT or PI3K-Akt signaling pathway, is a central signal transduction cascade that regulates key cellular processes such as metabolism, proliferation, survival, growth, and angiogenesis. It is initiated by extracellular signals via receptor tyrosine kinases or other receptors activating PI3K, leading to PIP3 production and AKT activation. Dysregulation is implicated in many cancers and contributes to insulin resistance/type 2 diabetes. Therapeutic strategies involve targeting various nodes within the pathway with small molecule inhibitors.
- Other names
- Protein Kinase B PathwayPKB/Akt PathwayPI3K-Akt Signaling
02
Mechanism of action
Inhibition of AKT kinase activity or upstream regulators to block downstream signaling.
03
Biological functions
Cell survival/apoptosis inhibitionProliferation/growth controlMetabolism regulationAngiogenesisProtein synthesisLysosomal biogenesis
04
Disease associations
CancerType 2 diabetesInsulin resistance
05
Safety considerations
HyperglycemiaDrug resistanceOff-target effects
06
Interacting drugs
AKT inhibitors
2 more in the full profile.
07
Biomarkers
PTEN lossPIK3CA mutationAKT phosphorylation status
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