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AKT-mTOR-p70S6K Pathway
- Target
- AKT-mTOR-p70S6K Pathway
- Molecular classification
- Signaling pathway
01
Overview
The AKT-mTOR-p70S6K pathway is a crucial intracellular signaling cascade that regulates cell growth, proliferation, survival, and metabolism. It integrates signals from growth factors and nutrients to control fundamental cellular processes. Dysregulation of this pathway is frequently observed in cancer, making it a major target for anticancer drug development.
- Other names
- PI3K/AKT/mTOR pathwayAKT/mTOR pathway
02
Mechanism of action
Inhibition of AKT, mTOR, or downstream targets like p70S6K leading to decreased cell growth and proliferation, and increased apoptosis.
03
Biological functions
Cell growthCell proliferationCell survivalMetabolismProtein synthesisRibosome biogenesisCell cycle progressionDendritic arborizationSynaptic plasticity
04
Disease associations
CancerTumorigenesisChemoresistance
05
Safety considerations
Off-target effects of inhibitorsDevelopment of resistanceImmunosuppression (with mTOR inhibitors)
06
Interacting drugs
AKT inhibitors
2 more in the full profile.
07
Biomarkers
Phosphorylation status of AKTPhosphorylation status of mTORPhosphorylation status of p70S6K
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