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Target intelligence / Profile preview
Alanine- and arginine-rich domain-containing protein (AARD)
- Target
- AARD
- Molecular classification
- Other (no established classification such as receptor, enzyme, transporter, etc.)
01
Overview
Alanine- and arginine-rich domain-containing protein (AARD) is a protein-coding gene highly expressed in a tissue- and stage-specific manner, especially in Sertoli cells within developing and adult testis, where its expression is directly regulated by the androgen receptor and induced by testosterone. Its transcript profile and regulation suggest a role in testicular differentiation, maintenance of male reproductive function, and spermatogenesis, though the precise biochemical function is not fully characterized. The encoded protein does not belong to any major molecular family (receptors, enzymes, etc.) currently recognized as typical drug targets. There is no evidence to suggest that AARD is directly therapeutically actionable or that it serves as a useful biomarker in human disease
- Other names
- C8orf85LOC441376chromosome 8 open reading frame 85alanine and arginine rich domain containing protein (unhyphenated form)Alanine and arginine-rich domain-containing protein (alternate punctuation)
02
Mechanism of action
Not applicable (no drugs known to interact directly)
03
Biological functions
Response to testosterone (implying a role in male reproductive function and possibly in spermatogenesis)Protein binding
04
Disease associations
No direct or established roles as a disease geneAssociation with Hermansky-Pudlak Syndrome 3 and Trichorhinophalangeal Syndrome, Type II (based on proximity or paralogy, not direct causation)Other (no established role in major disease categories like cancer, inflammation, etc.)
05
Safety considerations
None known; not a known therapeutic or diagnostic target
06
Interacting drugs
None known
07
Biomarkers
None reported or established
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