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Target intelligence / Profile preview
Alanine-serine-cysteine transporter 2 (ASCT2)
- Target
- ASCT2
- Molecular classification
- Solute Carrier Family 1, Transporter
01
Overview
Alanine-serine-cysteine transporter 2 (ASCT2), encoded by the SLC1A5 gene, is a sodium-dependent neutral amino acid transporter. It mediates the exchange of small neutral amino acids, primarily glutamine, alanine, and serine, across the plasma membrane. ASCT2 plays a crucial role in cancer metabolism by supplying glutamine for cell growth and proliferation and is a potential therapeutic target. While cysteine can bind, it is a potent inhibitor rather than a transported substrate. Inhibitors like GPNA and V9302 are being developed as anticancer agents.
- Other names
- SLC1A5
02
Mechanism of action
Inhibition of glutamine transport
03
Biological functions
Amino acid transportNutrient absorptionCell proliferationAmino acid homeostasis
04
Disease associations
CancerMetabolic dysregulation
05
Interacting drugs
GPNA
5 more in the full profile.
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