Alanyl-tRNA Synthetase (AlaRS)

Alanyl-tRNA synthetase (AlaRS) is an essential enzyme responsible for attaching alanine to its corresponding tRNA during protein synthesis. It belongs to the class IIc aminoacyl-tRNA synthetase family and plays a crucial role in maintaining the fidelity of translation. AlaRS possesses both aminoacylation and editing functions, ensuring that only the correct amino acid is incorporated into the growing polypeptide chain. It has a catalytic domain organized around an antiparallel beta sheet flanked by alpha helices, and mutations in related ARS enzymes can lead to human diseases.

Inhibition of tRNA aminoacylation, disruption of protein synthesis.