Albumin-rich Platelet-Rich Fibrin matrix (Alb-PRF)

Albumin-rich Platelet-Rich Fibrin (Alb-PRF) is an autologous biomaterial and bioactive scaffold used primarily in regenerative dentistry, oral surgery, and facial aesthetics [1, 6]. It is produced through a specialized centrifugation and heating process where the patient's platelet-poor plasma is thermally denatured to form a stable albumin gel, which is then combined with liquid platelet-rich fibrin containing concentrated platelets and leukocytes [4, 7]. This unique composition addresses the primary limitation of traditional PRF—its rapid resorption—by extending the matrix's structural integrity from two weeks to approximately four to six months [4, 8]. Alb-PRF serves as a biological reservoir that provides a sustained release of essential growth factors, including vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF), which are critical for angiogenesis and tissue healing [1, 2]. Clinically, it is employed to enhance bone grafting, treat periodontal defects, and improve soft tissue volume in aesthetic procedures [3, 7]. Its autologous nature ensures high biocompatibility and minimizes the risk of adverse immune reactions [2, 5].

Other names

Albumin-enriched Platelet-Rich FibrinAlb-CGFe-PRFBio-Heat membraneAlbumin gel-PRF mixture

Alb-PRF functions as a bioactive, autologous scaffold that provides a stable structural matrix for cell migration and tissue ingrowth. It is formed by combining thermally denatured serum albumin with liquid platelet-rich fibrin. This biphasic matrix allows for the slow and sustained release of regenerative molecules such as PDGF, VEGF, and TGF-beta over several weeks, significantly extending the resorption time compared to standard PRF. This sustained release stimulates angiogenesis, fibroblast activity, and osteoblast differentiation, facilitating both soft and hard tissue repair.