Target intelligence / Profile preview

Alcohol dehydrogenase 1C (ADH1C)

Target: ADH1C
Molecular classification: Enzyme, Oxidoreductase

Overview

ADH1C encodes the gamma subunit of class I alcohol dehydrogenase, an enzyme that catalyzes the oxidation of ethanol to acetaldehyde and plays a major role in alcohol metabolism. The enzyme also metabolizes various other substrates including retinol, aliphatic alcohols, and hydroxysteroids, making it important for multiple metabolic processes beyond alcohol catabolism.

Other names: ADH3Alcohol dehydrogenase subunit gammaADH gamma subunitAlcohol dehydrogenase 3 class I gamma polypeptideAldehyde reductase

Mechanism of action

Ethanol oxidation to acetaldehyde

Biological functions

Ethanol catabolismRetinol metabolismLipid peroxidation product metabolismSignal transduction

Disease associations

Alcohol dependenceParkinson's diseaseCancer (upper aerodigestive tract)

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