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Target intelligence / Profile preview
Alcohol dehydrogenase 6 (ADH6)
- Target
- ADH6
- Molecular classification
- Enzyme, Oxidoreductase, Alcohol dehydrogenase family
01
Overview
Alcohol dehydrogenase 6 (ADH6) is a class V enzyme in the alcohol dehydrogenase family responsible for the oxidation and reduction of a range of alcohols and aldehydes, including ethanol, retinol, and hydroxysteroids. Expressed predominantly in the liver and stomach, ADH6 contributes to detoxification and metabolic pathways. The gene contains regulatory elements for steroid hormone response, suggesting its expression can be modulated in specific physiological states. Its detailed substrate specificity and physiological role remain less characterized than other ADH family members, but it is implicated in general alcohol and aldehyde detoxification and associated disease risks.
- Other names
- ADH6Alcohol dehydrogenase 6Class V alcohol dehydrogenaseAldehyde reductaseADH-6ADH-5
02
Mechanism of action
NAD-dependent oxidation of primary alcohols to corresponding aldehydes, and secondary alcohols to ketones. Detoxification by oxidoreductase action prevents accumulation of toxic alcohols and aldehydes.
03
Biological functions
Metabolism of ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation productsDetoxification of endogenous and exogenous alcohols and aldehydes
04
Disease associations
Proliferative type fibrocystic change of breastAmed syndrome, digenicOther (general disorders of alcohol and aldehyde metabolism)
05
Safety considerations
Disruption or inhibition can affect metabolic clearance of alcohols and related compounds, potentially increasing toxicity (e.g., ethanol, methanol)Potential for off-target effects due to similarity among ADH isoforms/polymorphism
06
Interacting drugs
No specific drugs target ADH6 directly are widely reported, but the broader family is implicated in the metabolism of alcohol and aldehyde-containing drugs and toxins, including ethanol and methanol
1 more in the full profile.
07
Biomarkers
No routine, widely accepted biomarkers for patient selection or efficacy monitoring; ADH isoenzyme profiling may be relevant in alcohol-related disease risk but ADH6-specific markers are experimental
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