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Target intelligence / Profile preview
Aldehyde dehydrogenase 1 family member A1 (ALDH1A1)
- Target
- ALDH1A1
- Molecular classification
- Enzyme, Oxidoreductase
01
Overview
ALDH1A1 is a cytosolic enzyme that catalyzes the NAD(P)+–dependent oxidation of aldehydes, playing a role in detoxification and cellular metabolism. It is primarily known for oxidizing retinaldehyde to retinoic acid, regulating gene transcription involved in cell proliferation, differentiation, and development. It is also a cancer stem cell marker and contributes to chemoresistance.
- Other names
- ALDH1ALDH1AALDH1-1aldehyde dehydrogenase cytosolic
02
Mechanism of action
Enzyme inhibition
03
Biological functions
Retinol metabolismRetinoic acid signalingDetoxificationCell proliferationCell differentiationApoptosisDevelopmentRegulation of gene transcription
04
Disease associations
CancerOxidative stressDrug resistance
05
Safety considerations
ChemoresistancePotential for off-target effects with inhibitors
06
Interacting drugs
Disulfiram
07
Biomarkers
Cancer stem cell marker
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