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Target intelligence / Profile preview
Aldehyde dehydrogenase 3 family member A2 (ALDH3A2)
- Target
- ALDH3A2
- Molecular classification
- Enzyme, Aldehyde dehydrogenase
01
Overview
ALDH3A2 encodes fatty aldehyde dehydrogenase (FALDH), an enzyme that catalyzes the oxidation of medium and long-chain aliphatic aldehydes to fatty acids. This process is crucial for fatty acid metabolism and energy production. Mutations in ALDH3A2 cause Sjögren-Larsson syndrome, characterized by ichthyosis, neurological abnormalities, and eye problems, due to the accumulation of toxic fatty aldehydes.
- Other names
- Fatty aldehyde dehydrogenaseFALDHAL3A2_HUMANAldehyde dehydrogenase 10Microsomal aldehyde dehydrogenase
02
Mechanism of action
Oxidation of medium and long-chain aliphatic aldehydes to their corresponding fatty acids, utilizing NAD+ as a cofactor.
03
Biological functions
Fatty acid oxidationDetoxification of aldehydesSphingolipid metabolism
04
Disease associations
Sjögren-Larsson syndrome
05
Safety considerations
Accumulation of fatty aldehydes due to loss of function can disrupt cell membrane formation and function.Potential for off-target effects if developing inhibitors that also affect other aldehyde dehydrogenases.
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