Aldehyde dehydrogenase 3 family member B1 (ALDH3B1)

Aldehyde dehydrogenase 3 family member B1 (ALDH3B1) is a cytosolic enzyme in the aldehyde dehydrogenase superfamily. It detoxifies medium and long-chain aliphatic and aromatic aldehydes, many of which are cytotoxic byproducts of lipid peroxidation and oxidative stress[1][2][3][5]. ALDH3B1 is highly expressed in liver, kidney, lung, and certain brain regions, and its upregulation is observed in multiple tumor types, suggesting a potential role in cancer biology. Its main physiological function is to protect cells from the toxic and mutagenic effects of aldehydes, contributing to cellular homeostasis and resistance to oxidative injury[5][2][3]. Although not currently a primary therapeutic target, its expression and activity are of interest in oncology and diseases associated with oxidative stress[5][3][1].

Other names

Aldehyde dehydrogenase 3B1ALDH7Aldehyde dehydrogenase 7Long-chain fatty aldehyde dehydrogenaseMedium-chain fatty aldehyde dehydrogenaseALDH4

Aldehyde dehydrogenase inhibition would prevent the enzyme from converting toxic aldehydes to less toxic acids, potentially sensitizing cells to chemotherapeutic agents or increasing susceptibility to oxidative damage. No specific mechanism-of-action drugs for ALDH3B1 are reported in major pharmacological sources.