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Alder Pollen Protein (None)
- Target
- None
- Molecular classification
- Pathogenesis-related protein PR-10, PR-10 protein, Bet v 1 homolog
01
Overview
Alder pollen protein, primarily Aln g 1, is a major allergen belonging to the PR-10 protein family. It triggers allergic reactions such as rhinitis and conjunctivitis. Aln g 1 exhibits cross-reactivity with other tree pollens due to shared IgE-binding epitopes. It is considered a therapeutic target for potential immunotherapy due to the possibility of developing hypoallergenic variants.
- Other names
- Aln g 1European Alder Pollen AllergenGrey Alder Pollen Allergen
02
Mechanism of action
Site-directed mutagenesis to reduce IgE binding and lipid ligand affinity for potential immunotherapy.
03
Biological functions
Plant defenseAllergenIgE binding
04
Disease associations
Allergic rhinitisAllergic conjunctivitisPollen allergyOral Allergy Syndrome
05
Safety considerations
Cross-reactivity with other tree pollen allergens (Bet v 1, Cor a 1, etc.)Potential for anaphylaxis in highly sensitive individualsOral Allergy Syndrome
06
Biomarkers
Aln g 1 specific IgE levelsPR-10 protein levelsAlarmins in epithelial cells
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