Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Aldo-keto Reductase Family 1 Member B1
- Molecular classification
- Enzyme, Aldo/keto reductase superfamily
01
Overview
Aldo-keto reductase family 1 member B1 (AKR1B1), also known as aldose reductase, is an enzyme that catalyzes the NADPH-dependent reduction of a wide range of aldehydes and ketones to their corresponding alcohols. It plays a role in the polyol pathway, reducing glucose to sorbitol, which is implicated in diabetic complications. It also reduces toxic aldehydes and participates in prostaglandin synthesis. AKR1B1 is implicated in diabetes, cancer, oxidative stress diseases and cardiovascular pathologies making it a therapeutic target.
- Other names
- Aldose reductase
02
Mechanism of action
Inhibition of AKR1B1 enzyme activity
03
Biological functions
Reduction of aldehydes and ketonesGlucose metabolismOsmoregulationOxidative stress protectionProstaglandin F2α synthesis
04
Disease associations
Diabetic complicationsCancerOxidative stress diseasesCardiovascular disease
05
Safety considerations
Potential side effects of AKR1B1 inhibitorsComplex and sometimes opposing roles in cancer (inhibition may be beneficial in some cancers but detrimental in others)
06
Interacting drugs
AKR1B1 inhibitors
07
Biomarkers
AKR1B1 expression levels in adrenocortical cancer (potential malignancy marker)
Beyond the preview
Go deeper on Aldo-keto Reductase Family 1 Member B1.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Aldo-keto Reductase Family 1 Member B1.