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Target intelligence / Profile preview
Aldo-keto reductase family 1 member C1 (AKR1C1)
- Target
- AKR1C1
- Molecular classification
- Enzyme, Oxidoreductase, Aldo-keto reductase
01
Overview
Aldo-keto reductase family 1 member C1 (AKR1C1) is a cytosolic enzyme belonging to the aldo-keto reductase superfamily, which catalyzes the NADH- and NADPH-dependent reduction of aldehydes and ketones, particularly the conversion of progesterone to its inactive metabolite 20α-hydroxy-progesterone. This enzyme plays a critical role in steroid hormone metabolism, as well as in detoxifying endogenous and xenobiotic compounds. The gene is located on chromosome 10p15-p14 and shares high sequence identity with other AKR1C subfamily members[1][5].
- Other names
- 20α-hydroxysteroid dehydrogenase3α-hydroxysteroid dehydrogenasedihydrodiol dehydrogenase 1dihydrodiol dehydrogenase 2
02
Mechanism of action
Inhibition of steroid transforming enzyme activity, Modulation of hormone (e.g., progesterone) inactivation
03
Biological functions
Steroid metabolismHormone metabolismDetoxification of aldehydes and ketonesRegulation of hormone activity
04
Disease associations
CancerEndocrine disordersHormone-dependent diseasesInflammationLipedema
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