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AKR1C5P is a pseudogene related to the aldo-keto reductase (AKR1) family, specifically the family 1 member C5. Pseudogenes like AKR1C5P are genetic sequences similar to known genes but do not encode a functional protein due to disruptive mutations. Unlike other functional AKR1C enzymes involved in steroid hormone metabolism and disease processes, AKR1C5P does not contribute to enzymatic activity or drug interactions in humans[1]. AKR1 family members such as AKR1C1-AKR1C4 and AKR1D1 are well-studied enzymes significant in steroid hormone and drug metabolism, but AKR1C5P specifically is classified as a pseudogene, lacking biological function and relevance as a therapeutic target[1].
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