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Target intelligence / Profile preview
Aldose Reductase (AR)
- Target
- AR
- Molecular classification
- Enzyme, Oxidoreductase, Aldo-keto reductase superfamily
01
Overview
Aldose reductase (AR) is a cytosolic, NADPH-dependent oxidoreductase enzyme that catalyzes the reduction of a wide range of aldehydes and carbonyl compounds, including monosaccharides such as glucose. It is the first and rate-limiting enzyme in the polyol pathway, converting glucose to sorbitol. AR is strongly implicated in diabetic complications due to increased flux through the polyol pathway under hyperglycemic conditions. It is a therapeutic target for preventing or ameliorating these complications.
- Other names
- AKR1B1ALD2
02
Mechanism of action
Inhibition of aldose reductase enzyme activity, preventing the conversion of glucose to sorbitol.
03
Biological functions
Polyol pathway initiationGlucose to sorbitol conversionDetoxification of reactive aldehydesCell signaling via lipid aldehyde metabolismImmune response regulation
04
Disease associations
Diabetic neuropathyRetinopathyNephropathyCardiovascular diseaseDiabetes Mellitus Complications
05
Safety considerations
Potential for off-target effectsVariability in individual response due to genetic variations affecting AR expressionOxidative/nitrosative modifications affecting inhibitor sensitivity
06
Interacting drugs
Aldose reductase inhibitors (numerous)
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