ALG14 antisense RNA 1 (ALG14-AS1)

ALG14 antisense RNA 1 (also known as CNN3 divergent transcript or ALG14-AS1) is a long non-coding RNA gene located in the human genome adjacent to or overlapping with the ALG14 protein-coding gene. Unlike ALG14, which encodes a membrane-bound subunit critical for UDP-N-acetylglucosamine transferase activity in N-glycosylation and is associated with rare congenital disorders of glycosylation[1][2][3], ALG14-AS1 is a non-coding transcript with sparse or no evidence linking it to protein expression, therapeutic target status, or direct disease involvement. The function of ALG14-AS1 is presumed to be regulatory, consistent with other antisense RNA transcripts, but as of the current state of biomedical literature, there is minimal to no information on its specific biological or clinical significance. Key clarifications: - ALG14 antisense RNA 1 (ALG14-AS1, CNN3-DT, etc.) is not a recognized therapeutic target such as a receptor, enzyme, transporter, or transcription factor. - It is easy to confuse with the gene ALG14, which is an enzyme involved in protein N-glycosylation and associated with severe congenital disorders when mutated[1][2][3]. - There is no evidence that CNN3-DT/ALG14-AS1 encodes a protein or functions as a drug target. - No disease associations, drugs, mechanisms, or biomarkers are currently described for this lncRNA in the biomedical literature.

Other names

CNN3 divergent transcriptRP4-639F20.1hCG2028352-likeCNN3-DT