Alginate of Pseudomonas aeruginosa

Alginate of Pseudomonas aeruginosa refers to an extracellular polysaccharide produced by certain strains of the bacterium *P. aeruginosa*, particularly those exhibiting a mucoid phenotype often found in chronic lung infections such as cystic fibrosis[1]. Chemically, it consists mainly of D-mannuronic acid and L-guluronic acid residues. Alginate forms part of the bacterial extracellular matrix and helps protect bacteria from environmental stresses and host immune responses. While historically considered important for biofilm structure in *P. aeruginosa*, more recent evidence indicates that alginate is not the primary structural matrix component in most laboratory strains' biofilms; other polysaccharides like Pel and Psl play larger roles[2]. Alginate's overproduction remains clinically significant due to its association with persistent infection phenotypes. Note: "Alginate" itself is not a canonical therapeutic target like receptors or enzymes—it is an exopolysaccharide product rather than a protein or molecular entity typically targeted by drugs. The entry "Alginate of Pseudomonas aeruginosa" does not correspond to a conventional druggable target class but rather describes an important virulence factor produced by bacteria[1][2].

Other names

Pseudomonas aeruginosa alginateBacterial alginateMucoid exopolysaccharide (in the context of mucoid strains)