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Alkaline Phosphatase, Tissue-Nonspecific Isozyme (TNAP)

Target: TNAP
Molecular classification: Enzyme

Overview

Alkaline phosphatase, tissue-nonspecific isozyme (TNAP) is an enzyme encoded by the ALPL gene. It catalyzes the dephosphorylation of phosphate esters such as inorganic pyrophosphate (PPi), pyridoxal 5'-phosphate (PLP), and phosphoethanolamine (PEA). It plays a critical role in skeletal mineralization and vitamin B6 metabolism. Mutations cause hypophosphatasia with variable severity, affecting bone and tooth mineralization.

Other names: ALPLLiver/bone/kidney alkaline phosphatase

Mechanism of action

Inhibition of TNAP would theoretically prevent dephosphorylation of PPi, PLP and PEA.

Biological functions

DephosphorylationSkeletal mineralizationVitamin B6 metabolismHydrolyzing phosphate esters

Disease associations

HypophosphatasiaOsteomalaciaOdontomalacia

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