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Alkaline Phosphatase, Tissue-Nonspecific Isozyme (TNAP)
- Target
- TNAP
- Molecular classification
- Enzyme
01
Overview
Alkaline phosphatase, tissue-nonspecific isozyme (TNAP) is an enzyme encoded by the ALPL gene. It catalyzes the dephosphorylation of phosphate esters such as inorganic pyrophosphate (PPi), pyridoxal 5'-phosphate (PLP), and phosphoethanolamine (PEA). It plays a critical role in skeletal mineralization and vitamin B6 metabolism. Mutations cause hypophosphatasia with variable severity, affecting bone and tooth mineralization.
- Other names
- ALPLLiver/bone/kidney alkaline phosphatase
02
Mechanism of action
Inhibition of TNAP would theoretically prevent dephosphorylation of PPi, PLP and PEA.
03
Biological functions
DephosphorylationSkeletal mineralizationVitamin B6 metabolismHydrolyzing phosphate esters
04
Disease associations
HypophosphatasiaOsteomalaciaOdontomalacia
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