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Alkaline Phosphatase, Placental-Like 2 (ALPPL2)
- Target
- ALPPL2
- Molecular classification
- Enzyme, Hydrolase, Phosphatase, Membrane-bound glycoprotein
01
Overview
Alkaline Phosphatase, Placental-Like 2 (ALPPL2) is a membrane-bound glycosylated enzyme that belongs to the alkaline phosphatase family. It catalyzes the hydrolysis of phosphate esters. ALPPL2 is primarily localized in the testis, thymus, and certain germ cell tumors. It is closely related to intestinal and placental alkaline phosphatases. While placental alkaline phosphatase (PLAP) is a well-known tumor marker, ALPPL2 is also expressed in some testicular germ cell tumors and may serve as a marker for these malignancies.
- Other names
- ALPGGCAPALPPLAlkaline phosphatase Nagao isozymeGerm cell alkaline phosphatase
02
Biological functions
Phosphatase activityDephosphorylationCatalysisHydrolase activityMetal ion binding
03
Disease associations
CancerGerm cell tumors
04
Biomarkers
Testicular germ cell tumorsSeminomaOvarian cancer
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