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Target intelligence / Profile preview
Alkaline phosphatase germ cell (ALPPL2)
- Target
- ALPPL2
- Molecular classification
- Enzyme, Hydrolase, Membrane-bound protein, Glycoprotein
01
Overview
ALPPL2 (Alkaline Phosphatase, Placental-Like 2), also known as ALPG or GCAP, is a membrane-bound glycosylated enzyme belonging to the alkaline phosphatase family. It is highly expressed in certain tumor tissues, making it a potential target for antibody-drug conjugates and CAR T-cell therapies. ALPPL2 also plays roles in maintaining naïve pluripotency. It functions by catalyzing the hydrolysis of phosphate esters in an alkaline environment.
- Other names
- ALPGGCAPALPPLAlkaline Phosphatase, Placental-Like 2
02
Mechanism of action
Inhibition of enzymatic activity via antibody-drug conjugates or other targeted therapies.
03
Biological functions
Hydrolyzes phosphate estersMaintenance/initiation of naïve pluripotency
04
Disease associations
CancerSeminomaOvarian cancerEndometrial cancerTesticular cancersGonadoblastomaMesotheliomaPancreatic Cancer
05
Safety considerations
Potential off-target effects in placentaImmunogenicity of antibody-drug conjugates
06
Biomarkers
ALPPL2 expression in tumor tissueALPPL2 detection in extracellular vesicles
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