Allatotropin receptor (ATR)

Allatotropin is a neuropeptide first characterized in insects for its role in stimulating the biosynthesis of juvenile hormone, a master regulator of insect growth, metamorphosis, and reproduction[1][3][5][7][9]. Allatotropins are found in a wide range of invertebrates including insects, mollusks, flatworms, and some annelids, suggesting ancient evolutionary conservation[1][2][6][7]. The Allatotropin receptor (ATR) is a G protein-coupled receptor expressed in target tissues such as the corpora allata, accessory glands, heart, gut, and reproductive organs[3][4][5]. Activation of this receptor triggers intracellular signaling cascades that regulate hormone synthesis, muscle contractions, cardiac rhythm, digestive enzyme secretion, and reproductive physiology[2][3][4][5][6][7]. Allatotropin signaling is pivotal in insect biology but does not have a known role in human physiology or disease. No clinical drugs or biomarkers are associated with Allatotropin or its receptor. The process termed "Allatotropins secretion" refers to the physiological process of Allatotropin peptide release and does not denote a molecular target. The scientifically accurate target for structured database use is the Allatotropin receptor (ATR).

Other names

Allatotropin receptorATRAT receptorAeATr

Activation of Allatotropin receptor by Allatotropin triggers G protein signaling (primarily Gq/PLC/IP3/Ca2+ or Gs/cAMP pathways). Stimulation modulates downstream physiological effects: juvenile hormone synthesis, muscle contraction, secretion.