Target intelligence / Profile preview

Allergen

Molecular classification
Protein, Glycoprotein, Small molecule bound to carrier protein
01

Overview

An allergen is a typically harmless substance that can trigger an immune response in certain individuals, resulting in an allergic reaction. In these cases, the immune system mistakenly identifies the allergen as a threat and produces immunoglobulin E (IgE) antibodies specific to that substance. Upon subsequent exposures, these IgE antibodies bind to mast cells and basophils, leading to the release of inflammatory mediators such as histamine, which cause allergy symptoms.

Other names
Environmental allergensFood allergensInsect-related allergensDrug allergensContact allergens
02

Biological functions

Immune response elicitationMast cell activationBasophil activationIgE binding
03

Disease associations

Allergic rhinitisAllergic conjunctivitisAsthmaHivesAnaphylaxisFood allergyDrug allergyContact dermatitis
04

Safety considerations

AnaphylaxisCross-reactivity between allergensVariability in allergen potencyRisk of sensitization
05

Interacting drugs

Antihistamines

4 more in the full profile.

06

Biomarkers

Allergen-specific IgE levelsSkin prick test reactivityBasophil activation testComponent-resolved diagnostics (CRD)

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