Allergen from Dermatophagoides pteronyssinus (Der p allergen (for specific major allergens: Der p 1, Der p 2, etc.))

Allergens from Dermatophagoides pteronyssinus are a group of structurally and functionally diverse proteins produced by the house dust mite *Dermatophagoides pteronyssinus*, a principal source of indoor allergens responsible for allergic rhinitis, asthma, and atopic dermatitis in sensitized individuals. The best-characterized are the so-called major allergens, including Der p 1 (cysteine protease), Der p 2 (cholesterol-binding protein structurally related to the NPC2 family), Der p 5 (mid-tier allergen involved in protein dimerization), Der p 7 (structure similar to bactericidal permeability-increasing and lipopolysaccharide-binding proteins), and others. These allergens primarily function as immune sensitizers, eliciting IgE-mediated immune responses and triggering inflammatory cascades upon exposure in sensitized people. Structural studies have revealed their propensity to bind lipids or lipopeptides in some cases, which may modulate their allergenicity and interactions with the innate immune system[1][4][5][7]. **Note:** "Allergens from dermatophagoides pteronyssinus" is not a precise canonical target definition and encompasses at least 34 distinct proteins, each with different structural classes, biological functions, and clinical importance. For applications requiring structured data, a **single allergen (e.g., Der p 2)** should be specified for accurate mappings.

Other names

House dust mite allergenDermatophagoides pteronyssinus allergenHDM allergenDer p allergenSpecific examples include Der p 1, Der p 2, Der p 5, Der p 7, Der p 21, etc.[7]

Induction of IgE production, triggering mast cell and basophil degranulation - Allergen immunotherapy: induces immune tolerance via repeated controlled exposure