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Target intelligence / Profile preview
Allergen-Specific Immunoglobulin E (Allergen-Specific IgE)
- Target
- Allergen-Specific IgE
- Molecular classification
- Immunoglobulin, Antibody, IgE
01
Overview
Allergen-specific IgE antibodies are produced by B cells in response to allergen exposure. These antibodies bind to FcεRI receptors on mast cells and basophils. Upon re-exposure to the allergen, crosslinking of IgE on these cells triggers degranulation and the release of inflammatory mediators, leading to allergic symptoms. Allergen-specific IgE is the central mediator of Type I hypersensitivity reactions.
- Other names
- Allergen-Specific IgE AntibodySpecific IgEsIgE
02
Mechanism of action
Neutralizes free IgE, preventing binding to FcεRI on mast cells and basophils.
03
Biological functions
Allergen recognitionMast cell/basophil sensitizationInitiation of allergic responseB cell activation
04
Disease associations
Allergic rhinitisAsthmaUrticariaFood allergyAnaphylaxisAtopic dermatitis
05
Safety considerations
Potential for injection site reactionsRare risk of anaphylaxis with omalizumabEosinophilic conditions (rare)Potential for increased risk of certain infections
06
Interacting drugs
Omalizumab
07
Biomarkers
Total IgE levelsSpecific IgE levels (e.g., against specific allergens)
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