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Allergen-specific Immunotherapy Targeted at the Immune System (None)

Target
None
Molecular classification
Other
01

Overview

Allergen-specific immunotherapy is a medical treatment aimed at strengthening the immune system to gradually reduce symptoms associated with allergies. It involves exposing patients to small, increasing amounts of allergens to build tolerance over time. This approach can lead to long-term relief from allergies by modifying the immune response through several mechanisms, including the induction of regulatory T cells (Treg) and the suppression of effector T cells and IgE production.

Other names
Allergen ImmunotherapyAIT
02

Mechanism of action

Modulation of T- and B-cell responses, suppression of IgE and activation of mast cells and basophils, induction of IgG4 and Treg cells.

03

Biological functions

Immune response modulationTolerance induction
04

Disease associations

AllergiesInflammation
05

Safety considerations

Risk of systemic anaphylaxis during treatmentlocal reactions
06

Biomarkers

IgEIgG4 levelsTreg cell activity

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