Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Allergenic Proteins from Cucurbita Species
- Molecular classification
- Profilin, Lipid Transfer Protein (LTP), 11S Globulin, 2S Albumin, Seed Storage Proteins
01
Overview
Allergenic proteins from Cucurbita species (pumpkin, zucchini, and related squashes) are a group of plant-derived proteins capable of triggering IgE-mediated allergic reactions in sensitized individuals. Key allergens include profilin, lipid transfer proteins (LTPs), 11S globulins, and 2S albumins, found in both seeds and pulp. These proteins can cause reactions ranging from mild oral symptoms to severe anaphylaxis, and some exhibit cross-reactivity with other plant foods and pollens. LTPs are notable for their heat stability, retaining allergenicity even after cooking.
- Other names
- Pumpkin AllergensZucchini AllergensSquash AllergensCucurbita pepo allergensCucurbita maxima allergensCuc p 2Cuc ma 2Cuc ma 4Cuc ma 5
02
Biological functions
AllergenicityIgE-mediated allergic reactionsPlant defense (LTP)Nutrient storage (globulins, albumins)Actin binding (Profilin)
03
Disease associations
Food allergyAnaphylaxisOral Allergy SyndromeAllergic sensitization
04
Safety considerations
Anaphylactic shockCross-reactivity with other plant-derived foods and pollensVariability in allergen content among different Cucurbita varietiesHeat stability of some allergens (e.g., LTPs)
05
Biomarkers
Specific IgE levels to Cucurbita allergensSkin prick test reactivity to Cucurbita extracts
Beyond the preview
Go deeper on Allergenic Proteins from Cucurbita Species.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Allergenic Proteins from Cucurbita Species.