Target intelligence / Profile preview

Allergic Response Mediators (N/A)

Target
N/A
Molecular classification
Small molecule, Cytokine, Lipid mediator, Amine
01

Overview

Allergic response mediators are a group of molecules released primarily by mast cells and other immune cells during allergic reactions. These mediators are responsible for the symptoms observed in allergies, such as itching, swelling, bronchoconstriction, and increased mucus production. Their release is typically triggered when allergens cross-link IgE antibodies bound to high-affinity receptors (FcεRI) on mast cell surfaces.

Other names
Allergy MediatorsMast Cell MediatorsInflammatory Mediators (Allergy)
02

Mechanism of action

Bind to and activate specific receptors on target cells, leading to downstream signaling cascades that result in the characteristic symptoms of allergic reactions.

03

Biological functions

Immune responseInflammationVasodilationBronchoconstrictionSmooth muscle contractionIncreased vascular permeabilityEosinophil chemotaxisPlatelet aggregation
04

Disease associations

Allergic rhinitisAsthmaUrticariaAngioedemaAnaphylaxisMast Cell Activation Syndrome (MCAS)
05

Safety considerations

Systemic side effects (e.g., corticosteroids)Drug interactionsAnaphylaxis riskImmunosuppression
06

Interacting drugs

Antihistamines

4 more in the full profile.

07

Biomarkers

Histamine levelsLeukotriene levelsProstaglandin levelsIgE levelsTryptase levels

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